Preformulation and Formulation

Preformulation Services and Support

Characterization of the Active Pharmaceutical Ingredient (API) is critical to designing a successful formulation approach.  CoreRx can evaluate the characteristics of your API, conduct small scale studies to understand key parameters around solubility and stability, and perform excipient compatibility studies to identify the right ingredients to enhance your APIs performance across a variety of dosage forms.  Further, CoreRx has brought on-board various technologies to control and reduce particle size, which among other things, can greatly enhance the bioavailability of your compound.

Preformulation Services include:

  • API Physical & Chemical Characterization
  • pH/Solubility Profile
  • Partition Coefficient
  • Thermal Analysis
  • Hygroscopicity Evaluation
  • Chemical & Physical Stability Evaluations

Particle Size Control & Reduction Technologies:

  • Jet Mill (Dry Process)
    – Particle size range of 1 – 45 microns
  • Microfluidization (Wet Process)
    – Particle size reduction for submicron and nano-sized particles
  • Proprietary MicroJetReactor (MJR®), Nanosizer (Wet Process)
    – Extreme particle size reduction for nano-sized particles down to
    100nm

Formulation Development

Our robust experience and capabilities in formulation development covers a wide range of dosage forms and delivery technologies.  Keeping our client’s goals and objectives in mind, we focus on creating formulations designed to meet our client’s needs.  From early phase formulations for preclinical research through QBD evaluations , CoreRx can support your formulation needs for any phase of development.

Overcoming Formulation Challenges

Developing formulations is as much an art as it is a science, and it’s the people that make the difference.  Our formulation team consists of PhD and Masters level formulators and chemists that we would stack up against any in the Industry.

From these experts, we provide guidance and support across the following areas:

  • Solubilizing water-insoluble drugs
  • Stabilizing unstable molecules
  • Enhancing bioavailability

  • Taste masking/flavoring
  • Creating modified/controlled release delivery of API
  • Creating fixed dose combination products

Dosage Form Experience

Solids Semi-Solids Liquids Specialty

Formulation Technologies

Solid Dosage Forms

– Blending
– Dry Granulation/Roller Compaction
– Wet Granulation
– Fluid Bed Drying
– Spray Drying
– Extrusion/Spheronization
– Encapsulation
– Tableting including (Micro and Multi-Layer)
– Pan Coating/Drying

Liquid & Semi-Solid Dosage Forms

– Mixing
– Homogenization
– Filling
– Lyophilization

Partner with us

When you’re ready to get expertise, flexibility, and reliability with your pharmaceutical formulation project, call us or fill out this form. We’ll be happy to answer your questions, provide a tour of our facilities, and get your project started today.