CoreRx has great depth and breadth of scientific experience and success in developing unique and innovative formulations that help our clients achieve their drug program goals
Whether as part of life-cycle management, as a differentiating dosing approach, enabling targeted drug release in support of improving therapeutic benefit, to meet particular intellectual property requirements, or modifying a new or existing drug to improve palatability, ease of administration or other patient benefit, CoreRx applies forward-thinking approaches to meeting our partners’ drug development needs.
Bioenhancement and Improved Solubility
CoreRx applies various techniques and technologies to enhance drug product solubility and improve bioavailability, and applies our knowledge and experience ensure the formulation meets the targeted bioavailability goals. Our approach, methods and processes help us determine the particle engineering and formulation approach best suited to the compound and to our partner’s goals. We start with API characterization.
Characterization: CoreRx develops data on thermal properties, particle size distribution, morphology, and other factors that can yield insights into which method may best deliver the intended bioavailability approach and desired results.
Determining approach: broadly, there are three different types of bioavailability enhancement approaches: physical, chemical, and complexation. Physical modification may include micronization, solid state dispersion, and creation of nanoparticles. Chemical approaches may include a change in pH, use of a buffer, or different salt form of the molecule. Complexation entails combining the molecule with other agents such as cyclodextrins or hydrophobic materials which can often have a dramatic effect on solubility and bioenhancement.
Specialized Dosage Forms
CoreRx can provide our partners with virtually any solid oral, liquid and topical dosage form, formulated to suit your specific needs, manufactured and packaged from clinical-scale to commercial scale, and supported by our robust Quality Systems, Scientific, and Project Management teams. In addition to our most commonly provided immediate and modified release solid oral, liquid and topical formulations and finished-dosage products, CoreRx can also formulate, manufacture and supply the following:
- Orally Disintegrating (ODT)
- Multi-Layer Tablets
- Micro-Tablets
- Multi-API Combination Products
- Powder Blends
- Multi-particulates (beads & granules)
- Tablet in capsule
- Over-encapsulation (for comparator blinding)
- Multi-API Combination Products
Packaged and dispensed in oral syringes
Including suppositories and powders
Learn more about how CoreRx applies our expertise and knowledge to provide innovative solutions to meet drug program needs
